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Stress

 

DHEA levels are closely tied to stress. Studies have shown that stress caused by traumatic events such as burns or illnesses significantly decrease DHEA, testosterone, and androstenedione levels, while increasing the level of cortisol. Calmness, such as seen in individuals practicing transcendental meditation, is associated with higher levels of DHEA.

 

Clinical Studies

Researchers at the National Center for Post-Traumatic Stress Disorder have found that the hormone dehydroepiandrosterone-S (DHEA-S), which is known to enhance memory and reduce depression and aggression in mice, appears to have a role in coping with stress.
 

Soldiers, studied during grueling military survival school exercises, were found to have the fewest symptoms of dissociation, which is known to present a higher risk of developing post traumatic stress disorder, were found in the soldiers with the highest ratio of DHEA-S to the stress hormone, cortisol. They also performed better under pressure, in terms of the survival school exercises. This appears to indicate that the DHEA-S acts as a buffer against a negative stress impact but it is not known exactly what determines how much is produced.
 

In one study, participants in a stress-reduction program increased DHEA by 100% and reduced stress hormone production (cortisol) by 23%.
 

Institute of Physiology, Russian Academy of Medical Sciences, Siberian Branch, Institute of Cytology and Genetics, Russian Academy of Sciences, Siberian Branch, Novosibirsk.
Effects of dehydroepiandrosterone sulfate (DHEAS, 30 mg/kg, i.p., 4 and 28 hours after the injection) were studied in CBA/Lac male mice different in the level of anxiety resulting from repeated social victories (winners) or social defeats (losers) in 10 daily agonistic confrontations. The losers demonstrated high level of anxiety estimated by the "partition" test. The DHEAS and saline injections had different effects on winners, losers, and intact mice. DHEAS prevented the development of anxiety in losers 28 hours after the injection. In these experimental conditions DHEAS exerted no effect on winners. It was concluded that the DHEAS effect depends on the psychoemotional state of an animal. The anxiolytic effect of the exogenous DHEAS may be also characteristic of the endogenous hormone secreted by the adrenal glands and in the central nervous system.

 

 

 

 

 

 

 

 

 




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