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Systemic Lupus Erythematosus


Lupus is an autoimmune disorder. Autoimmune diseases are a group of conditions in which a person's antibodies attack a part of their own body because the immune system believes the body part is foreign.

DHEA improves the testosterone and estrogen levels in body, which plays an important role in strengthening immune system. As lupus disorders are autoimmune diseases, DHEA is thought to be helpful in the treatment of lupus by providing immune support. It has also been observed that estrogen and testosterone levels are often unbalanced in women suffering from lupus disease. DHEA supplements can therefore redress this balance and contribute towards lupus treatment.

DHEA can also be used to treat the symptoms of lupus disease, providing instant relief while the disease itself subsides. DHEA reduces the production of inflammatory cytokines such as cytokine IL-4, 5, and 6 that can cause the most common lupus symptoms. It also plays an important role in enhancing the production of cytokine IL-2, an anti-inflammatory that can reduce
lupus symptoms.

The majority of clinical trials investigating the effect of DHEA for systemic lupus erythematosus support its use as an adjunct treatment.


Clinical Studies

  • A double-blind, placebo-controlled study conducted on 120 women suffering from Systemic Lupus Erythematosus (SLE) showed that 200 mg of DHEA daily can significantly decrease the symptoms of lupus.

  • The Genelabs study, conducted on 191 women with lupus at 27 medical centers, showed that women who were taking 200 milligram doses of DHEA could reduce their daily dosage of prednisone and still have equivalent relief of pain, inflammation and fatigue. The women also reported that they felt better.

  • Genelabs-sponsored one-year, multi-center trial of 370 women with lupus is nearing completion; it's looking at whether GL701 also improves or stabilizes disease activity, such as rashes and frequency of flares. The trial ends in March, and some researchers are optimistic that a prescription DHEA lupus drug may be approved for use in mild-to-moderate cases within two to three years. The GL701 form of DHEA is not available outside the study.










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