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Cancers and DHEA

 

DHEA has been found to improve function and to have significant anti-cancer and anti-tumor effects.

DHEA owes many of its beneficial properties to fight cancer due to its ability to inhibit an enzyme called glucose-6-phosphate dehydrogenase (G6PD). DHEA's cardioprotective properties may also be partly due to G6PD inhibition.

Cervical cancer
Initial research reports that the use of intravaginal DHEA may be safe and may promote regression of low-grade cervical lesions. Patients should not substitute the use of DHEA for more established therapies, and they should discuss management options and follow-up with a primary healthcare professional or gynecologist.

 

Clinical Studies

  • In long-term study of 5,000 women it was found that DHEA levels fell drastically up to nine years before the development of breast cancer. The highest risk factor for cancer was low levels of DHEA. DHEA has been shown to enhance immunity, prevent cancer, and prolong life in laboratory animals.

  • Nine healthy elderly men with an average age of 64 years took 50 mg nightly of DHEA for 20 weeks. DHEA treatment significantly elevated natural killer cells. These are lymphocytes that are involved in searching out and destroying not only viruses, but abnormal cells that are on their way to turning cancerous. Although the number of T lymphocytes was unaffected, T cell function was increased (as measured by an increased proliferative response to phytohemagglutinin, a chemical that normally stimulates T cells). B cell function was also increased.

  • Sahelian chronicles a study that was conducted on mice and rats. In this experiment, DHEA was shown to inhibit the development of experimental tumors of the liver, breast, lung, colon, skin lymphatic tissue and other bodily tissues.
    Among pregnant rats implanted with a cancer-causing agent, 96 percent of the controls developed mammary (breast) tumors. Mice that were supplemented with DHEA but that otherwise received the same cancer-causing treatment had only a 35 percent incidence of mammary tumors. Dr. Inano, a Japanese researcher, concluded, "These findings suggest that DHEA has a potent preventive activity against the promotion/progression phase of radiation-induced mammary tumorigenesis."

  • DHEA lowers cancer enzyme Glucose-6-Phosphate Dehyrogenase (G6PD). British women having 10% less DHEA than that expected for their age group, developed and died from breast cancer, predicted by low urine DHEA tested 9 years prior; inhibits lung tumors from urethane and 1,2 dimethylbenz-anthracene, skin cancers (100 mg./ day), blocks colon tumors in mice from carcinogen 1,2-dimethylhydrazine, inhibits prostate cancer, and testicle tumors in rodents.

  • One study showed that patients with adult T-cell leukemia (ATL) had significantly decreased levels of DHEA compared to healthy controls. This has led some doctors to speculate that DHEA might be beneficial in treating this form of leukemia because DHEA has already been shown effective in treating leukemia.

  • Other cancer studies show DHEA inhibits cancer cell thymidine incorporation needed for cellular propagation and disrupts the oxidizing effects of chemical carcinogens. Scientists point out that DHEA functions not as an antioxidant, but as a modulator of the effects of chemical carcinogens on cells.

  • A human clinical study of 129 advanced cancer patients on 40 mg of DHEA per day found that while there wasn't significant regression of the cancer, two patients with renal cancer stabilized their conditions and tolerated the DHEA therapy without side effects for two and a half years. And according to Regelson and Kalimi, DHEA may be our bestagent for blocking stress-mediated support of tumor growth.

 

 




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