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DHEA HISTORY
 

Subjects found on this page :

Discovered in the 1930s...

1960:  DHEA-S is produced by the corticosuprarenal gland

DHEA has anti-aging properties...

" Pill of Youth " mediatization

Year 2000...

Today...

Bibliography

 

Discovered in the 1930s...

It is in 1931 that Dr. Adolf BUTERNANDT (1), a German fellow, isolates DHEA in its free form, in human urine. This doctor obtained the Nobel Prize for chemistry a few years later, in 1939.

In 1944, the sulphated form of DHEA is isolated (DHEA-S).

It is only 20 years later, in 1954, that two researchers, Migeon and Plager (2), isolate DHEA in human blood, and precise histological studies (Symington, 1956) (3) indicate that it is produced by the internal part of the suprarenal cortex.

In 1958, the French man Max Fernand JAYLE, professor of biochemistry at the Faculty of Medicine of Paris, manages to proportion precisely the quasi linear decrease of DHEA in men and women progressively with aging (professor Etienne-Emile BAULIEU was one of his pupils).


1960: DHEA-S is produced by the corticosuprarenal gland

Professor Étienne-Emile Baulieu's (4) research on a case of human suprarenal tumor in 1960, brings the proof that DHEA was well synthesized by the suprarenal glands, but in the form of dehydroepiandrosterone sulphate  (DHEA-S).

In men, the metabolism of DHEA and DHEA-S was particularly studied during the 1960s, by oral administration  or intravenous injection (use generally of compounds marked by radioactive isotopes). Thus, the transformation of DHEA into DHEA-S and the metabolism of DHEA in androgens and estrogens was confirmed. It was significant to show that the metabolism of DHEA-S involves the formation of the same derivatives as DHEA itself (Vande Wiele R.L., 1963) (5).

In the 1970s, a series of international studies showed the possibility for beneficial effects of DHEA on animals. These many works were undertaken on laboratory animals (rats and mice especially), studying the effects of the administration of DHEA generally mixed with food.

Kalimi and Regelson (1990) (6), Thijssen and Nieuwenhuyse (1999) (7) and Bellino and Al (1995) (8) showed that DHEA at high dosage could: 
- prolong the existence of the animals,
- prevent certain cancers and viral diseases,
- treat certain obesities of genetic origin,
- protect against atherosclerosis.

These results are to be put in critical prospect. The reality of the observations is not questioned, but their interpretation and their extrapolation with the human problems are difficult.

DHEA has anti-aging properties...

We waited until 1994 for Professor Samuel YEN of the University of San Diego, California, to publish the first results of the positive tests on men, which confirmed that DHEA has anti-aging properties. Indeed, the administration of DHEA to elderly patients involves biological, physical, and psychological changes.

Alex Vermeulen, professor at the hospital of Gand, said in the first international conference on DHEA, organized by the Academy of Science of New York in 1995, that "DHEA has a positive effect on the wellbeing, the response to vaccination, and memory, and is very active against artherosclerosis." It is in the same year that DHEA was authorized by the FDA in the United States.

In 1996, at the hospital of Laval, Quebec, Fernand Labrie discovered the slight increase of bone density in treated subjects. It is proof of the great importance of DHEA in the fight against osteoporosis.

At last, other observations established on one hand a relation between the use of DHEA and the reduction of fat overload, and on the other hand, the reduction of risk factors for cardiovascular diseases.

Note: it was established that the DHEA blood rate of people contaminated with the AIDS virus is very low.

"Pill of Youth" mediatization

In a parallel way, publicity around DHEA started in the United States after a study published at the Medical school of the University of San Diego. The researchers who wanted to show the effects of DHEA on the organism showed evident the improvement of the physical and psychological wellbeing of the patients, and of their sleep, as well as a greater facility to fight against stress.

Other studies also showed the possible benefits which DHEA could bring to patients affected by a great number of diseases such as diabetes, obesity, cancer, dermatosis etc...

From this moment on, DHEA was profusely spoken of in the Medias and was presented as
"The Hormone of Youth".

Year 2000...

At the Broussais Hospital in Paris, Professors Jayle and Kazatchkine gave 100 mg/day for 4 months to seropositive subjects with the AIDS virus. No toxic effects have been noted to date. The results are still not published.

It was also noted that DHEA increases sensitivity to thyroid hormones, improving the thermo genesis, the metabolism of slightly fat individuals, and energy production.

In April 2000, Professor Baulieu (9) publishes the results of the study "DHEAGE" which studies 280 volunteers over 60 years old taking 50 mg of DHEA per day during one year.
The results are proven and are positive for the women. It is probable that men require stronger amounts (75 to100mg per day).

In November 2000: crucial turn. The French Medical Authorities authorize the sale of DHEA. However DHEA still does not have a MA (Marketing Authorization) in France, but, thanks to a gap in the law, it can be sold in pharmacy, in the form of masterly preparation.

Today...

It is your turn to benefit from this "Universal Cure" as millions of people already do.
We receive testimonials every week of happy and satisfied people. 

Bibliography

1/ Butenandt A. et Dannenbaum H., 1934. Z physiol, Vol. 229, 192.

2/ Migeon C.J. et Plager J.E., 1954. J Biol Chem, Vol. 209, 767.

3/ Symington T., Duguid W.P. et Davidson J.J., 1956. J Clin Endocrinol Metab, Vol. 16, 580. Effect of exogenous corticotropin on the histochemical pattern of the human adrenal cortex and a comparison with the changes during stress.

4/ Baulieu E.E., 1960. C.R. Acad Sci, Vol. 251, 1421-1423. Esters-sulfates de stéroïdes hormonaux. Isolement de l'ester-sulfase de 5-androstène 3b -ol 17-one (déhydroépiandrostérone) dans une tumeur cortico-surrénalienne. Absence de stéroïde libre.

5/ Vande Wiele R.L., MacDonald P.C., Gurpide E., Lieberman S., 1963.Recent Progress in Hormone Research, Vol. 19, p.275-310. Studies on the secretion and Intervention.

6/ Kalimi M. et Regelson W. eds, 1990. The Biologic Role of Dehydroepiandrosterone (DHEA) (Walter de Gruyter Pub.).

7/ Thijssen J.H.H. and Nieuwenhuyse H., 1999. Parthenon Publishing Group, DHEA a comprehensive review, p.35-68 - Neuroactive neurosteroids: DHEA and DHEA-S.

8/ Bellino F.C., Daynes R.A., Hornsby P.J., Lavrin L.H., Nestler J.E. Vol. 774. 1995 Ann. NY Acad Sci. DHEA and Aging.

9/ Baulieu E.E. et al, 2000. Proceedings of the National Academy of Sciences, USA. Vol. 97, No.8, p.4279-4284. DHEA, DHEA Sulfate and aging: Contribution of the DHEAge Study to a sociobiomedical.

 




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