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Discovered in the
1930s...
1960:
DHEA-S is produced by the corticosuprarenal gland
DHEA has anti-aging
properties...
" Pill of Youth " mediatization
Year 2000...
Today...
Bibliography
Discovered in the
1930s...
It is in 1931 that Dr. Adolf BUTERNANDT (1), a German fellow,
isolates DHEA in its free form, in human urine. This doctor
obtained the Nobel Prize for chemistry a few years later, in 1939.
In 1944, the sulphated form of DHEA is isolated (DHEA-S).
It is only 20 years later, in 1954, that two researchers, Migeon and
Plager (2), isolate DHEA in human blood, and precise
histological studies (Symington, 1956) (3) indicate that it is produced
by the internal part of the suprarenal cortex.
In 1958, the French man Max Fernand JAYLE, professor of biochemistry
at the Faculty of Medicine of Paris, manages to proportion precisely the
quasi linear decrease of DHEA in men and women progressively with
aging (professor Etienne-Emile BAULIEU was one of his pupils).
1960:
DHEA-S is produced by the corticosuprarenal gland
Professor Étienne-Emile Baulieu's (4) research on a case of human
suprarenal tumor in 1960, brings the proof that DHEA was well
synthesized by the suprarenal glands, but in the form of
dehydroepiandrosterone sulphate (DHEA-S).
In men, the metabolism of DHEA and DHEA-S was particularly studied
during the 1960s, by oral administration or
intravenous injection (use generally of compounds marked by radioactive isotopes). Thus, the transformation of
DHEA into DHEA-S and the
metabolism of DHEA in androgens and estrogens was confirmed. It
was significant to show that the metabolism of DHEA-S involves the
formation of the same derivatives as DHEA itself (Vande Wiele R.L., 1963) (5).
In the 1970s, a series of international studies showed the possibility
for beneficial effects of DHEA on animals. These many works were
undertaken on laboratory animals (rats and mice especially),
studying the effects of the administration of DHEA generally mixed with
food.
Kalimi and Regelson (1990) (6), Thijssen and Nieuwenhuyse (1999) (7)
and Bellino and Al (1995) (8) showed that DHEA at high dosage
could:
- prolong the existence of the animals,
- prevent certain cancers and viral diseases,
- treat certain obesities of genetic origin,
- protect against atherosclerosis.
These results are to be put in critical prospect. The reality of the
observations is not questioned, but their interpretation and their
extrapolation with the human problems are difficult.
DHEA has
anti-aging properties...
We waited until 1994 for Professor Samuel YEN of
the University of San Diego, California, to publish the first results of
the positive tests on men, which confirmed that DHEA has anti-aging
properties. Indeed, the administration of DHEA to elderly patients
involves biological, physical, and psychological changes.
Alex Vermeulen, professor at the hospital of Gand, said in the first
international conference on DHEA, organized by the Academy of
Science of New York in 1995, that "DHEA has a positive effect on
the wellbeing, the response to vaccination, and memory, and is very
active against artherosclerosis." It is in the same year that DHEA was authorized by the
FDA in the United States.
In 1996, at the hospital of Laval, Quebec, Fernand Labrie discovered
the slight increase of bone density in treated subjects. It is proof of the
great importance of DHEA in the fight against osteoporosis.
At last, other observations established on one hand a relation between
the use of DHEA and the reduction of fat overload, and on the other hand,
the reduction of risk factors for cardiovascular diseases.
Note: it was established that the DHEA blood rate of people
contaminated with the AIDS virus is very low.
"Pill of
Youth" mediatization
In a parallel way, publicity around DHEA started in the United States after a study published at the
Medical school of the University of San
Diego. The researchers who wanted to show the effects of DHEA on
the organism showed evident the improvement of the physical and
psychological wellbeing of the patients, and of their sleep, as well as a
greater facility to fight against stress.
Other studies also showed the possible benefits which DHEA could bring
to patients affected by a great number of diseases such as diabetes,
obesity, cancer, dermatosis etc...
From this moment on, DHEA was profusely spoken of in the Medias and
was presented as
"The Hormone of Youth".
Year 2000...
At the Broussais Hospital in Paris, Professors Jayle and Kazatchkine
gave 100 mg/day for 4 months to seropositive subjects with the AIDS virus.
No toxic effects have been noted to date. The results are still not published.
It was also noted that DHEA increases sensitivity to thyroid hormones, improving the
thermo genesis, the metabolism of slightly fat individuals, and energy production.
In April 2000, Professor Baulieu (9) publishes the results of the
study "DHEAGE" which studies 280 volunteers over 60 years
old taking 50 mg of DHEA per day during one year.
The results are proven
and are positive for the women. It is probable that men require stronger
amounts (75 to100mg per day).
In November 2000: crucial turn. The French Medical Authorities
authorize the sale of DHEA. However DHEA still does not have a
MA (Marketing Authorization) in France, but, thanks to a gap in the law,
it can be sold in pharmacy, in the form of masterly preparation.
Today...
It is your turn to benefit from this "Universal Cure"
as millions of people already do.
We receive testimonials every week of
happy and satisfied people.
Bibliography
1/ Butenandt A. et Dannenbaum H., 1934. Z physiol, Vol.
229, 192.
2/ Migeon C.J. et Plager J.E., 1954. J Biol Chem, Vol.
209, 767.
3/ Symington T., Duguid W.P. et Davidson J.J., 1956. J
Clin Endocrinol Metab, Vol. 16, 580. Effect of exogenous corticotropin on
the histochemical pattern of the human adrenal cortex and a comparison
with the changes during stress.
4/ Baulieu E.E., 1960. C.R. Acad Sci, Vol. 251,
1421-1423. Esters-sulfates de stéroïdes hormonaux. Isolement de
l'ester-sulfase de 5-androstène 3b -ol 17-one (déhydroépiandrostérone)
dans une tumeur cortico-surrénalienne. Absence de stéroïde libre.
5/ Vande Wiele R.L., MacDonald P.C., Gurpide E.,
Lieberman S., 1963.Recent Progress in Hormone Research, Vol. 19,
p.275-310. Studies on the secretion and Intervention.
6/ Kalimi M. et Regelson W. eds, 1990. The Biologic Role
of Dehydroepiandrosterone (DHEA) (Walter de Gruyter Pub.).
7/ Thijssen J.H.H. and Nieuwenhuyse H., 1999. Parthenon
Publishing Group, DHEA a comprehensive review, p.35-68 - Neuroactive
neurosteroids: DHEA and DHEA-S.
8/ Bellino F.C., Daynes R.A., Hornsby P.J., Lavrin L.H.,
Nestler J.E. Vol. 774. 1995 Ann. NY Acad Sci. DHEA and Aging.
9/ Baulieu E.E. et al, 2000. Proceedings of the National
Academy of Sciences, USA. Vol. 97, No.8, p.4279-4284. DHEA, DHEA Sulfate
and aging: Contribution of the DHEAge Study to a sociobiomedical.
